CSNK1A1
Gene Information
- Official Symbol: CSNK1A1
- Official Name: casein kinase 1 alpha 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1452
- UniProt: P48729
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| beta-catenin destruction complex assembly |
| regulation of GTP binding |
| beta-catenin destruction complex |
| mRNA cleavage and polyadenylation specificity factor complex |
| beta-catenin destruction complex disassembly |
| intermediate filament cytoskeleton organization |
| intermediate filament-based process |
| kinase activity |
| peptidyl-threonine phosphorylation |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| condensed chromosome kinetochore |
| canonical Wnt signaling pathway |
| peptidyl-threonine modification |
| positive regulation of ubiquitin-dependent protein catabolic process |
| keratin filament |
| positive regulation of proteasomal protein catabolic process |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Golgi organization |
| ciliary basal body |
| positive regulation of cellular protein catabolic process |
| regulation of ubiquitin-dependent protein catabolic process |
| ribonucleoprotein complex |
| negative regulation of canonical Wnt signaling pathway |
| peptidyl-serine phosphorylation |
| regulation of proteasomal protein catabolic process |
| cilium |
| peptidyl-serine modification |
| negative regulation of Wnt signaling pathway |
| positive regulation of protein catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| protein kinase activity |
| protein-containing complex disassembly |
| regulation of cellular protein catabolic process |
| regulation of canonical Wnt signaling pathway |
| cell-cell signaling by wnt |
| positive regulation of proteolysis |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| protein serine/threonine kinase activity |
| positive regulation of cellular catabolic process |
| regulation of binding |
| regulation of protein catabolic process |
| cellular component disassembly |
| nuclear speck |
| endomembrane system organization |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| positive regulation of catabolic process |
| centrosome |
| cell division |
| cell morphogenesis |
| regulation of proteolysis |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| peptidyl-amino acid modification |
| protein phosphorylation |
| regulation of catabolic process |
| cytoskeleton organization |
| cell-cell signaling |
| negative regulation of signal transduction |
| phosphorylation |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| ATP binding |
| protein-containing complex assembly |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of protein metabolic process |
| protein-containing complex subunit organization |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 42/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 4/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 181
- Expression level (log2 read counts): 5.9
Expression Distribution
CSNK1A1 Expression in NALM6 Cells: 5.9
