DDX6
Gene Information
- Official Symbol: DDX6
- Official Name: DEAD-box helicase 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 1656
- UniProt: P26196
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:26098573}.
Pfam Domains GO Terms
Pfam Domains
| Helicase C |
| DEAD |
GO Terms
| concave side of sperm head |
| viral RNA genome packaging |
| viral genome packaging |
| outer dense fiber |
| sperm annulus |
| chromatoid body |
| cytoplasmic mRNA processing body assembly |
| RISC complex |
| stress granule assembly |
| heterochromatin |
| exonucleolytic catabolism of deadenylated mRNA |
| helicase activity |
| nuclear-transcribed mRNA catabolic process, exonucleolytic |
| virion assembly |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| RNA helicase activity |
| cytoplasmic stress granule |
| cytoplasmic ribonucleoprotein granule |
| P-body |
| cell-cell adherens junction |
| stem cell population maintenance |
| maintenance of cell number |
| spermatid differentiation |
| mRNA binding |
| nuclear-transcribed mRNA catabolic process |
| viral life cycle |
| mRNA catabolic process |
| negative regulation of neuron differentiation |
| ribonucleoprotein complex assembly |
| protein domain specific binding |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| negative regulation of neurogenesis |
| cadherin binding |
| negative regulation of nervous system development |
| negative regulation of cell development |
| cellular process involved in reproduction in multicellular organism |
| nucleobase-containing compound catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| organic cyclic compound catabolic process |
| spermatogenesis |
| male gamete generation |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| gamete generation |
| mRNA metabolic process |
| perinuclear region of cytoplasm |
| viral process |
| negative regulation of cell differentiation |
| organelle assembly |
| symbiotic process |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| cellular protein-containing complex assembly |
| multicellular organism reproduction |
| nucleolus |
| cellular macromolecule catabolic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| multi-organism reproductive process |
| macromolecule catabolic process |
| negative regulation of multicellular organismal process |
| mitochondrion |
| RNA binding |
| reproductive process |
| reproduction |
| ATP binding |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| RNA metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 120/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 7/28 |
| blood | 5/28 |
| bone | 5/26 |
| breast | 6/33 |
| central nervous system | 10/56 |
| cervix | 1/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 4/16 |
| kidney | 5/21 |
| liver | 3/20 |
| lung | 6/75 |
| lymphocyte | 4/16 |
| ovary | 3/26 |
| pancreas | 4/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 6/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1505
- Expression level (log2 read counts): 8.17
Expression Distribution
DDX6 Expression in NALM6 Cells: 8.17
