EIF1

Gene Information

Official Symbol: EIF1
Official Name: eukaryotic translation initiation factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 10209
UniProt: P41567
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.71
Ethanol 0.01 R05 exp234	-2.11
Vemurafenib 6.6μM R08 exp434	-2.1
Campthothecin 0.001μM R06 exp270	-2.03
CR131-b 0.005μM R08 exp474	-1.91
Bortezomib 0.005μM R00 exp6	-1.83
Clomiphene 4.4μM R02 exp68	-1.82
Rapamycin 10μM R00 exp30	-1.7
Nocodazole 0.2μM R02 exp64	1.7
RS-1 10μM R08 exp519	1.91
Rotenone 20μM R00 exp34	1.93
BI-2536 0.02μM R03 exp96	1.94
Methotrexate 0.01μM R08 exp501	2.02
Arsenate 40μM R06 exp264	2.02
R-DABN 8μM R03 exp111	2.09
Cannabidiol 13μM R08 exp465	2.13
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.32

Global Fraction of Cell Lines Where Essential: 120/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	4/26
breast	10/33
central nervous system	7/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	4/20
lung	7/75
lymphocyte	1/16
ovary	5/26
pancreas	3/24
peripheral nervous system	8/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1877
Expression level (log2 read counts): 8.18

Expression Distribution