MBIP
Gene Information
- Official Symbol: MBIP
- Official Name: MAP3K12 binding inhibitory protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51562
- UniProt: Q9NS73
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| inactivation of MAPK activity involved in osmosensory signaling pathway |
| molybdopterin synthase activity |
| osmosensory signaling pathway |
| molybdopterin cofactor biosynthetic process |
| prosthetic group metabolic process |
| molybdopterin cofactor metabolic process |
| Ada2/Gcn5/Ada3 transcription activator complex |
| inactivation of MAPK activity |
| protein kinase inhibitor activity |
| cellular response to osmotic stress |
| histone H3 acetylation |
| negative regulation of MAP kinase activity |
| response to osmotic stress |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| negative regulation of protein serine/threonine kinase activity |
| protein acetylation |
| negative regulation of MAPK cascade |
| protein acylation |
| cofactor biosynthetic process |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| coenzyme metabolic process |
| negative regulation of transferase activity |
| peptidyl-lysine modification |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| regulation of MAP kinase activity |
| histone modification |
| covalent chromatin modification |
| negative regulation of protein phosphorylation |
| cofactor metabolic process |
| negative regulation of phosphorylation |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| organophosphate biosynthetic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| chromatin organization |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| nucleolus |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| organophosphate metabolic process |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| identical protein binding |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular response to stress |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9603
- Expression level (log2 read counts): 4.36
Expression Distribution
MBIP Expression in NALM6 Cells: 4.36
