NIN
Gene Information
- Official Symbol: NIN
- Official Name: ninein
- Aliases and Previous Symbols: N/A
- Entrez ID: 51199
- UniProt: Q8N4C6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| centrosome-templated microtubule nucleation |
| corpus callosum morphogenesis |
| corticospinal tract morphogenesis |
| microtubule nucleation by microtubule organizing center |
| microtubule minus-end |
| collateral sprouting |
| ciliary transition fiber |
| centriolar subdistal appendage |
| microtubule anchoring at centrosome |
| microtubule anchoring at microtubule organizing center |
| centriole-centriole cohesion |
| corpus callosum development |
| microtubule nucleation |
| pericentriolar material |
| central nervous system projection neuron axonogenesis |
| microtubule anchoring |
| mitotic spindle pole |
| axonal growth cone |
| centrosome localization |
| positive regulation of microtubule polymerization |
| microtubule organizing center localization |
| microtubule polymerization |
| positive regulation of microtubule polymerization or depolymerization |
| central nervous system neuron axonogenesis |
| microtubule polymerization or depolymerization |
| regulation of microtubule polymerization |
| apical part of cell |
| mitotic spindle |
| central nervous system neuron development |
| regulation of microtubule polymerization or depolymerization |
| centrosome cycle |
| positive regulation of axonogenesis |
| protein polymerization |
| developmental cell growth |
| cell growth |
| microtubule organizing center organization |
| kinase binding |
| developmental growth involved in morphogenesis |
| spindle pole |
| positive regulation of protein polymerization |
| centriole |
| positive regulation of cell morphogenesis involved in differentiation |
| central nervous system neuron differentiation |
| regulation of axonogenesis |
| regulation of microtubule cytoskeleton organization |
| positive regulation of supramolecular fiber organization |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| positive regulation of protein complex assembly |
| telencephalon development |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| regulation of supramolecular fiber organization |
| positive regulation of neuron differentiation |
| axonogenesis |
| positive regulation of cell projection organization |
| forebrain development |
| developmental growth |
| GTP binding |
| growth |
| axon development |
| dendrite |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| centrosome |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of cellular component biogenesis |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cell morphogenesis involved in differentiation |
| organelle localization |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| neuron projection development |
| microtubule-based process |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| calcium ion binding |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| cellular protein-containing complex assembly |
| nucleolus |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| central nervous system development |
| cell cycle process |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 20μM R00 exp26 | -1.76 |
| Epothilone-B 0.0015μM R05 exp231 | 1.78 |
| RO-3307 4.7μM R02 exp80 | 2.18 |
| Cytochalasin-B 5μM R07 exp349 | 4.51 |
| Latrunculin-B 10μM R07 exp374 | 4.64 |
| Tozasertib 0.1μM R07 exp414 | 5.81 |
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17110
- Expression level (log2 read counts): 8.58
Expression Distribution
NIN Expression in NALM6 Cells: 8.58
