NMT1
Gene Information
- Official Symbol: NMT1
- Official Name: N-myristoyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4836
- UniProt: P30419
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.
Pfam Domains GO Terms
Pfam Domains
| NMT |
| NMT C |
GO Terms
| myristoyltransferase activity |
| glycylpeptide N-tetradecanoyltransferase activity |
| N-terminal peptidyl-glycine N-myristoylation |
| peptidyl-glycine modification |
| protein myristoylation |
| N-terminal protein myristoylation |
| N-terminal protein lipidation |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of rhodopsin mediated signaling pathway |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| N-terminal protein amino acid modification |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| positive regulation of establishment of protein localization to mitochondrion |
| extrinsic component of membrane |
| cellular ketone metabolic process |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| regulation of membrane permeability |
| protein lipidation |
| lipoprotein biosynthetic process |
| positive regulation of mitochondrion organization |
| lipoprotein metabolic process |
| positive regulation of protein localization to membrane |
| mitochondrial membrane organization |
| regulation of G protein-coupled receptor signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| protein acylation |
| regulation of protein localization to membrane |
| mitochondrial transport |
| positive regulation of cellular protein localization |
| in utero embryonic development |
| regulation of apoptotic signaling pathway |
| mitochondrion organization |
| positive regulation of establishment of protein localization |
| regulation of cellular protein localization |
| positive regulation of organelle organization |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| positive regulation of cell death |
| regulation of establishment of protein localization |
| membrane organization |
| peptidyl-amino acid modification |
| regulation of cellular localization |
| embryo development |
| positive regulation of transport |
| regulation of protein localization |
| regulation of response to external stimulus |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of organelle organization |
| organonitrogen compound biosynthetic process |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 353/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 14/28 |
| blood | 15/28 |
| bone | 11/26 |
| breast | 16/33 |
| central nervous system | 22/56 |
| cervix | 2/4 |
| colorectal | 12/17 |
| esophagus | 9/13 |
| fibroblast | 0/1 |
| gastric | 11/16 |
| kidney | 2/21 |
| liver | 11/20 |
| lung | 33/75 |
| lymphocyte | 11/16 |
| ovary | 10/26 |
| pancreas | 12/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 11/15 |
| prostate | 0/1 |
| skin | 10/24 |
| soft tissue | 4/9 |
| thyroid | 0/2 |
| upper aerodigestive | 17/22 |
| urinary tract | 19/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1976
- Expression level (log2 read counts): 7.04
Expression Distribution
NMT1 Expression in NALM6 Cells: 7.04
