PDS5A
Gene Information
- Official Symbol: PDS5A
- Official Name: PDS5 cohesin associated factor A
- Aliases and Previous Symbols: N/A
- Entrez ID: 23244
- UniProt: Q29RF7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
- UniProt Summary: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 19051
- Expression level (log2 read counts): 8.07
PDS5A Expression in NALM6 Cells: 8.07
