PHACTR4
Gene Information
- Official Symbol: PHACTR4
- Official Name: phosphatase and actin regulator 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 65979
- UniProt: Q8IZ21
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RPEL |
GO Terms
| negative regulation of integrin-mediated signaling pathway |
| closure of optic fissure |
| optic cup morphogenesis involved in camera-type eye development |
| protein phosphatase activator activity |
| embryonic camera-type eye formation |
| enteric nervous system development |
| regulation of integrin-mediated signaling pathway |
| protein phosphatase 1 binding |
| embryonic camera-type eye morphogenesis |
| embryonic eye morphogenesis |
| embryonic camera-type eye development |
| autonomic nervous system development |
| morphogenesis of an epithelial sheet |
| neural crest cell migration |
| Rho protein signal transduction |
| neural crest cell development |
| stem cell development |
| mesenchymal cell development |
| neural crest cell differentiation |
| neural tube closure |
| tube closure |
| primary neural tube formation |
| neural tube formation |
| camera-type eye morphogenesis |
| regulation of phosphoprotein phosphatase activity |
| embryonic epithelial tube formation |
| epithelial tube formation |
| regulation of protein dephosphorylation |
| morphogenesis of embryonic epithelium |
| eye morphogenesis |
| tube formation |
| mesenchymal cell differentiation |
| stem cell differentiation |
| neural tube development |
| ameboidal-type cell migration |
| regulation of phosphatase activity |
| lamellipodium |
| regulation of dephosphorylation |
| mesenchyme development |
| Ras protein signal transduction |
| sensory organ morphogenesis |
| actin binding |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| camera-type eye development |
| small GTPase mediated signal transduction |
| eye development |
| visual system development |
| sensory system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| actin cytoskeleton organization |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| tube development |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| cell migration |
| embryo development |
| cell motility |
| localization of cell |
| cytoskeleton organization |
| epithelium development |
| regulation of cell cycle |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| negative regulation of response to stimulus |
| cell development |
| intracellular signal transduction |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11979
- Expression level (log2 read counts): 5.98
Expression Distribution
PHACTR4 Expression in NALM6 Cells: 5.98
