PPA1
Gene Information
- Official Symbol: PPA1
- Official Name: inorganic pyrophosphatase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5464
- UniProt: Q15181
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pyrophosphatase |
GO Terms
| diphosphate metabolic process |
| inorganic diphosphatase activity |
| tRNA aminoacylation for protein translation |
| tRNA aminoacylation |
| amino acid activation |
| tRNA metabolic process |
| magnesium ion binding |
| cellular amino acid metabolic process |
| translation |
| peptide biosynthetic process |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| carboxylic acid metabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 583/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 21/28 |
| blood | 22/28 |
| bone | 23/26 |
| breast | 16/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 11/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 13/16 |
| kidney | 18/21 |
| liver | 16/20 |
| lung | 55/75 |
| lymphocyte | 11/16 |
| ovary | 17/26 |
| pancreas | 21/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 9/15 |
| prostate | 0/1 |
| skin | 22/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 23/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 715
- Expression level (log2 read counts): 7.02
Expression Distribution
PPA1 Expression in NALM6 Cells: 7.02
