PRPF18
Gene Information
- Official Symbol: PRPF18
- Official Name: pre-mRNA processing factor 18
- Aliases and Previous Symbols: N/A
- Entrez ID: 8559
- UniProt: Q99633
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Participates in the second step of pre-mRNA splicing. {ECO:0000269|PubMed:9000057}.
Pfam Domains GO Terms
Pfam Domains
| PRP4 |
| Prp18 |
GO Terms
| U2-type post-spliceosomal complex |
| nuclear mRNA surveillance of spliceosomal pre-mRNA splicing |
| generation of catalytic spliceosome for second transesterification step |
| nuclear retention of unspliced pre-mRNA at the site of transcription |
| second spliceosomal transesterification activity |
| nuclear retention of pre-mRNA at the site of transcription |
| spliceosomal conformational changes to generate catalytic conformation |
| intracellular mRNA localization |
| nuclear RNA surveillance |
| nuclear mRNA surveillance |
| RNA surveillance |
| U5 snRNP |
| U4/U6 x U5 tri-snRNP complex |
| spliceosomal complex |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA localization |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| nucleobase-containing compound catabolic process |
| RNA splicing |
| nuclear speck |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| mRNA processing |
| organic cyclic compound catabolic process |
| mRNA metabolic process |
| cellular protein-containing complex assembly |
| RNA processing |
| cellular macromolecule catabolic process |
| macromolecule catabolic process |
| protein-containing complex assembly |
| cellular macromolecule localization |
| RNA metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1569
- Expression level (log2 read counts): 4.48
Expression Distribution
PRPF18 Expression in NALM6 Cells: 4.48
