QKI

Entrez Summary: The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.04
BVD-523 15μM R02 exp67	-1.97
3-Bromopyruvate 7μM R04 exp175	-1.95
UM0011500 10μM R05 exp246	-1.95
UM131593 0.2μM R03 exp106	-1.95
Rotenone 0.07μM R08 exp431	-1.74
Lead acetate 2000μM R08 exp498 no dilution day6	1.7
Ribavirin 10 to 15μM on day4 R04 exp160	1.71
FTY720 3μM R08 exp483	1.77
Pomalidomide 20μM R07 exp391	1.8
ETC-159 50μM R08 exp480	1.84
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.9
Tubacin 1.6μM R07 exp416	2.92
Dynasore 10μM R04 exp180	3

Gene	Correlation
FAM122A	0.411

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution