SAP30

Entrez Summary: N/A
UniProt Summary: Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-2.12
Clomiphene 4.4μM R02 exp68	-2.08
UM131593 0.2μM R03 exp106	-2.02
S-trityl-L-cysteine 0.5μM R05 exp243	-1.96
Vemurafenib 6.6μM R08 exp434	-1.95
UM0129480 7μM R02 exp85	-1.9
GSK626616 14μM R08 exp485	-1.85
Prochlorperazine 5.2μM R02 exp77	-1.85
Vinblastine 0.002μM R01 exp60	-1.78
Apcin 25μM plus proTAME 2μM R04 exp177	-1.77
MS023 2μM R03 exp134	-1.73
Benzoate 10000μM R08 exp455	-1.71
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.7
THZ531 0.225μM R08 exp444	1.75
ML-792 0.2μM R08 exp505	1.78

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution