UniProt Summary: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Mito carr
GO Terms
iron import into the mitochondrion
iron ion transmembrane transporter activity
iron ion transmembrane transport
iron ion transport
iron ion homeostasis
mitochondrial transmembrane transport
transition metal ion transport
transition metal ion homeostasis
mitochondrial transport
mitochondrial inner membrane
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
metal ion transport
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
ion homeostasis
cation transport
ion transmembrane transport
chemical homeostasis
transmembrane transport
ion transport
homeostatic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)