TADA2B
Gene Information
- Official Symbol: TADA2B
- Official Name: transcriptional adaptor 2B
- Aliases and Previous Symbols: N/A
- Entrez ID: 93624
- UniProt: Q86TJ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}.
Pfam Domains GO Terms
Pfam Domains
| Myb DNA-binding |
GO Terms
| SAGA-type complex |
| STAGA complex |
| positive regulation of histone acetylation |
| positive regulation of peptidyl-lysine acetylation |
| positive regulation of protein acetylation |
| histone acetyltransferase activity |
| regulation of histone acetylation |
| regulation of peptidyl-lysine acetylation |
| regulation of protein acetylation |
| positive regulation of histone modification |
| positive regulation of chromatin organization |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| protein acetylation |
| regulation of histone modification |
| chromatin remodeling |
| positive regulation of chromosome organization |
| protein acylation |
| regulation of chromatin organization |
| protein deubiquitination |
| transcription coactivator activity |
| protein modification by small protein removal |
| peptidyl-lysine modification |
| regulation of chromosome organization |
| histone modification |
| covalent chromatin modification |
| chromatin binding |
| positive regulation of organelle organization |
| chromatin organization |
| zinc ion binding |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| chromosome organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| proteolysis |
| regulation of organelle organization |
| DNA binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 2μM R03 exp134 | -1.72 |
| THZ1 0.06μM R08 exp531 | 1.74 |
| Hinokiflavone 12μM R08 exp487 | 1.79 |
| Quercetin 20μM R08 exp517 | 2.03 |
| Colchicine 0.009μM R05 exp215 | 2.07 |
| UM131593 0.2μM R03 exp106 | 2.74 |
| 3-Bromopyruvate 7μM R04 exp175 | 3.32 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SUPT7L | 0.725 |
| TAF6L | 0.667 |
| TAF5L | 0.652 |
| TADA1 | 0.604 |
| TADA3 | 0.56 |
| KAT2A | 0.556 |
| MED13L | 0.55 |
| MED13 | 0.543 |
| SUPT20H | 0.517 |
| ATXN7 | 0.508 |
| CCDC101 | 0.496 |
| MED7 | 0.474 |
| PRR12 | 0.457 |
| MLLT1 | 0.456 |
| BRPF1 | 0.448 |
| ZMIZ1 | 0.445 |
| GLTSCR1 | 0.443 |
| MED23 | 0.44 |
| USP22 | 0.438 |
| ID3 | 0.435 |
| UBE3A | 0.422 |
| TLE4 | 0.422 |
| RUNX1 | 0.419 |
| TCEB3 | 0.413 |
| PRKAR1A | 0.402 |
| ATXN7L3 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 20/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/25 |
| breast | 4/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 1/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 581
- Expression level (log2 read counts): 5.18
Expression Distribution
TADA2B Expression in NALM6 Cells: 5.18
