Table of Contents

KU-0063794 3.8μM R02 exp71

Mechanism of Action

ATP-competitive mTORC1 and mTORC2 inhibitor

Technical Notes

Protein References

  • PubChem Name: Ku-0063794
  • Synonyms: N/A
  • CAS #: 938440-64-3
  • PubChem CID: 16736978
  • IUPAC: [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
  • INCHI Name: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
  • INCHI Key: RFSMUFRPPYDYRD-CALCHBBNSA-N
  • Molecular Weight: 465.5
  • Canonical SMILES: CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
  • Isomeric SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
  • Molecular Formula: C25H31N5O4

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1226
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C25H31N5O4 466.24488; found 466.246

Dose Response Curve

  • Platform ID: KU-0063794
  • Min: -18.4031; Max: 67.0870





IC Concentration (µM)
IC10 N/A
IC20 1.9729
IC30 2.9378
IC40 4.0717
IC50 5.4936
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
4/3ScoresViewViewViewViewView