DIMT1

Entrez Summary: N/A
UniProt Summary: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). {ECO:0000269|PubMed:25851604}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Methyltransf 18
RrnaAD

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
rRNA (adenine-N6,N6-)-dimethyltransferase activity
positive regulation of ribosome biogenesis
positive regulation of rRNA processing
regulation of rRNA processing
regulation of ribosome biogenesis
rRNA methylation
rRNA modification
RNA methylation
RNA modification
rRNA processing
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
mitochondrial matrix
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
positive regulation of cellular component biogenesis
nucleolus
RNA processing
regulation of cellular component biogenesis
RNA binding
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of gene expression
gene expression