NUCKS1

Gene Information

Official Symbol: NUCKS1
Official Name: nuclear casein kinase and cyclin dependent kinase substrate 1
Aliases and Previous Symbols: N/A
Entrez ID: 64710
UniProt: Q9H1E3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sulforaphane 9μM R08 exp525	1.7
Temozolomide 200μM R04 exp189	1.74
Golgicide-A 4μM R03 exp122	1.85
Zebularine 20μM R07 exp423	1.85
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.9
MSC2530818 10μM R07 exp379	1.93

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16790
Expression level (log2 read counts): 8.83

Expression Distribution

modulation by host of RNA binding by virus
modulation by host of viral RNA-binding transcription factor activity
regulation of RNA binding transcription factor activity
release from viral latency
regulation of DNA strand elongation
latent virus replication
modulation by host of viral transcription
modulation by host of viral molecular function
gene conversion
positive regulation by host of viral genome replication
modulation by host of symbiont molecular function
cellular response to X-ray
modulation of molecular function in other organism
modulation of molecular function in other organism involved in symbiotic interaction
negative regulation by host of viral process
regulation of RNA binding
viral latency
negative regulation by host of viral transcription
modulation by host of viral genome replication
positive regulation by host of viral process
positive regulation by host of viral transcription
positive regulation of insulin receptor signaling pathway
positive regulation of cellular response to insulin stimulus
negative regulation of viral transcription
modulation by host of viral process
response to X-ray
replication fork processing
positive regulation of viral genome replication
DNA-dependent DNA replication maintenance of fidelity
positive regulation of viral transcription
interstrand cross-link repair
positive regulation of viral life cycle
regulation of viral transcription
regulation of insulin receptor signaling pathway
cellular response to ionizing radiation
modification by host of symbiont morphology or physiology
regulation of cellular response to insulin stimulus
interaction with symbiont
cellular glucose homeostasis
regulation of viral genome replication