TSPYL1

Entrez Summary: The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.95
TRAIL 50ng/ml R00 exp36	-2.38
Deferoxamine 11μM R07 exp350	-2.31
TRAIL 5ng/ml R00 exp35	-2.31
Wortmannin 5μM R00 exp38	-2.12
Hydroxychloroquine 30μM R08 exp490	-2.05
Pimelic-diphenylamide-106 5μM R00 exp28	-2.01
MLN-4924 2μM R00 exp22	-1.98
DABN 20μM R00 exp17	-1.9
GSK2606414 1μM R05 exp236	-1.82
Lead acetate 2000μM R08 exp498 no dilution day6	1.7
Trimetrexate 0.03μM R08 exp535	1.75
Pomalidomide 20μM R07 exp391	1.79
AICAR 240μM R03 exp116	1.85
Citral 50μM R06 exp274	1.89
Ibrutinib 10μM R08 exp442	1.9
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.04
THZ531 0.225μM R08 exp444	2.04
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.13
RO-3307 4.7μM R02 exp80	2.21
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.31
Rapamycin 10μM R00 exp30	2.37
ML-792 0.2μM R08 exp505	2.59
Nifuroxazide 5μM R03 exp102	2.61
THZ531 0.11μM R07 exp409	2.65
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.71
THZ531 0.11 to 0.125μM on day4 R07 exp410	3.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome assembly
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
enzyme binding
chromatin organization
cellular protein-containing complex assembly
nucleolus
chromosome organization
protein-containing complex assembly
protein-containing complex subunit organization