A-366 10μM R03 exp115
Mechanism of Action
Inhibits G9a/EHMT1, blocks methylation of H3K9
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: CID 76285486
- Synonyms: N/A
- CAS #: 1527503-11-2
- PubChem CID: 76285486
- IUPAC: 5'-methoxy-6'-(3-pyrrolidin-1-ylpropoxy)spiro[cyclobutane-1,3'-indole]-2'-amine
- INCHI Name: InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
- INCHI Key: BKCDJTRMYWSXMC-UHFFFAOYSA-N
- Molecular Weight: 329.4
- Canonical SMILES: COC1=C(C=C2C(=C1)C3(CCC3)C(=N2)N)OCCCN4CCCC4
- Isomeric SMILES: N/A
- Molecular Formula: C19H27N3O2
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H27N3O2 330.2176; found 330.21771
Dose Response Curve
- Platform ID: A366
- Min: 2.0657; Max: 13.4619
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 10µM
- Days of incubation: 8
- Doublings: 7.4
- Numbers of reads: 10792747
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/1 | Scores |
A-366 10μM R03 exp115
