Alda-1 10μM R06 exp262
Mechanism of Action
Activates mitochondrial aldehyde dehydrogenase (ALDH2), may attenuate ethanol addiction
- Class / Subclass 1: Metabolism / Metabolic Enzyme Activator
Technical Notes
Compound References
- PubChem Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
- Synonyms: N/A
- CAS #: 349438-38-6
- PubChem CID: 831629
- IUPAC: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
- INCHI Name: InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
- INCHI Key: NMKJFZCBCIUYHI-UHFFFAOYSA-N
- Molecular Weight: 324.2
- Canonical SMILES: C1OC2=C(O1)C=C(C=C2)CNC(=O)C3=C(C=CC=C3Cl)Cl
- Isomeric SMILES: N/A
- Molecular Formula: C15H11Cl2NO3
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: A514590
- Lot #: 1-ARD-48-4
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C15H11Cl2NO3 324.01888; found 324.0189
Dose Response Curve
- Platform ID: Alda1
- Min: -16.4759; Max: 23.5071
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 10µM
- Days of incubation: 8
- Doublings: 7.4
- Numbers of reads: 7248085
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Alda-1 10μM R06 exp262
