Salubrinal 20μM R07 exp399 [The Human Chemical-Genetic Interaction Map Project]

Inhibits eIF2‘± phosphatase, indirectly inhibits eIF2‘±

Class / Subclass 1: Proteostasis / Translation Inhibitor

Compound References

PubChem Name: Salubrinal
Synonyms: N/A
CAS #: 405060-95-9
PubChem CID: 5717801
IUPAC: (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
INCHI Name: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
INCHI Key: LCOIAYJMPKXARU-VAWYXSNFSA-N
Molecular Weight: 479.8
Canonical SMILES: C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
Isomeric SMILES: C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
Molecular Formula: C21H17Cl3N4OS

Compound Supplier

Supplier Name: Toronto Research Chemicals
Catalog #: S100550
Lot #: 6-SXG-126-1

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H17Cl3N4OS 479.02614; found 479.02862

Dose Response Curve

Platform ID: Salubrinal
Min: -20.2185; Max: 15.7327

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 20µM
Days of incubation: 8
Doublings: 4.7
Numbers of reads: 22757578

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
PARL	-3.01	0.02
ADCK3	-2.86	0.02
PDSS1	-2.46	0.14
ASB3	-2.45	0.15
KIAA1432	-2.42	0.14
CEPT1	-2.40	0.14
USE1	-2.33	0.15
TAF5L	-2.30	0.23
PEX7	-2.30	0.15
ATP6V1D	-2.23	0.26
OPA3	-2.18	0.23
CRCP	-2.16	0.32
TCF4	-2.16	0.23
LOC147646	-2.16	0.23
PCSK7	-2.13	0.23
BCL11A	-2.13	0.23
ALG5	-2.07	0.27
PPP2R2A	-2.07	0.27
TRAF2	-2.04	0.32
ARFRP1	-2.04	0.32
TSC1	-2.03	0.32
C13orf45	-2.03	0.32
LMOD1	-2.02	0.47
EXOC6B	-2.02	0.32
CXXC11	-2.01	0.32
ZDHHC5	-1.99	0.36
KHDRBS1	-1.98	0.32
CSNK2A1	-1.98	0.36
OR4K17	-1.98	0.32
CHD8	-1.97	0.36
CRNKL1	1.96	0.57
CHRNB1	1.97	0.51
DPH3	1.98	0.48
ATP6V0A2	2.00	0.48
ZXDB	2.00	0.48
BRMS1	2.01	0.54
GRHL1	2.01	0.48
ZCWPW1	2.01	0.48
PPM1G	2.02	0.48
WDR4	2.03	0.41
UVRAG	2.04	0.41
CDK8	2.06	0.48
CEP95	2.07	0.37
SHMT2	2.09	0.48
RBM39	2.10	0.62
ESD	2.17	0.28
KMT2D	2.23	0.27
ZNF217	2.23	0.34
PMVK	2.24	0.27
CKAP5	2.24	0.54
FAM98B	2.27	0.27
LUC7L	2.27	0.29
MORN2	2.27	0.54
OR51D1	2.27	0.27
CXorf64	2.30	0.28
GDNF	2.31	0.27
HSPE1	2.34	0.57
METTL1	2.50	0.27
RBM26	2.68	0.17
SGTA	2.79	0.06

Last modified: 2026/01/15 21:36
by 127.0.0.1