Pyrazinamide 100μM R08 exp516
Mechanism of Action
Inhibits growth of Mycobacterium tuberculosis in combination with isoniazid, ethambutanol and rifampicin, converted to active pyrazinamide by pyrazinamidase
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Pyrazinamide
- Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide
- CAS #: 98-96-4
- PubChem CID: 1046
- IUPAC: pyrazine-2-carboxamide
- INCHI Name: InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
- INCHI Key: IPEHBUMCGVEMRF-UHFFFAOYSA-N
- Molecular Weight: 123.11
- Canonical SMILES: C1=CN=C(C=N1)C(=O)N
- Isomeric SMILES: N/A
- Molecular Formula: C5H5N3O
Compound Supplier
- Supplier Name: Combi-Blocks
- Catalog #: OR-0062
- Lot #: B76356
Compound Characterization
- LCMS: Tr 0.23 min, m/z invisible, Lambda max 208, 270 nm
Dose Response Curve
- Platform ID: Pyrazinamide
- Min: -11.1628; Max: 33.7224
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 08
- Dose: 100µM
- Days of incubation: 8
- Doublings: 7.0
- Numbers of reads: 18655839
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Pyrazinamide 100μM R08 exp516
