Vitamin-D3 40μM R08 exp536
Mechanism of Action
Steroid hormone, converted to active 1,25-dihydroxycholecalciferol (calcitriol), role in calcium homeostasis
- Class / Subclass 1: Metabolism / Vitamin
- Class / Subclass 2: Metabolism / Metabolite
- Class / Subclass 3: SIgnal Transduction / Receptor Ligand
Technical Notes
Compound References
- PubChem Name: Cholecalciferol
- Synonyms: Vitamin D3; Colecalciferol
- CAS #: 67-97-0
- PubChem CID: 5280795
- IUPAC: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
- INCHI Name: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
- INCHI Key: QYSXJUFSXHHAJI-YRZJJWOYSA-N
- Molecular Weight: 384.6
- Canonical SMILES: CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
- Isomeric SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C
- Molecular Formula: SGQVYFGIIA F
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: V676045
- Lot #: 1-LXM-62-1
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C27H44O 385.34649; found 385.34677
Dose Response Curve
- Platform ID: Vitamin_D3
- Min: -4.9823; Max: 99.7060
| IC | Concentration (µM) |
|---|---|
| IC10 | 43.1100 |
| IC20 | 49.9600 |
| IC30 | 55.1000 |
| IC40 | 59.7100 |
| IC50 | 64.2800 |
| IC60 | 69.2000 |
| IC70 | 74.9900 |
| IC80 | 82.7100 |
| IC90 | 95.8400 |
Screen Summary
- Round: 08
- Dose: 40µM
- Days of incubation: 8
- Doublings: -0.4
- Numbers of reads: 16653208
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/5 | Scores |
Vitamin-D3 40μM R08 exp536
ONC212 0.15μM R08 exp513 vs Vitamin-D3 40μM R08 exp536
