LIPT1
Gene Information
- Official Symbol: LIPT1
- Official Name: lipoyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51601
- UniProt: Q9Y234
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011].
- UniProt Summary: Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 692
- Expression level (log2 read counts): 3.48
LIPT1 Expression in NALM6 Cells: 3.48
