ZC3H7A

Entrez Summary: N/A
UniProt Summary: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CVT-10216 0.1μM R06 exp278	-2.08
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.76
Aphidicolin 0.4μM R08 exp440	1.73
Hydroxyurea 100μM R07 exp329	1.78
Docosahexaenoic-acid 50μM R07 exp356	1.87
Diepoxybutane 3μM R07 exp354	1.88
Nocodazole 0.2μM R02 exp64	1.88
Actinomycin-D 0.001μM R00 exp3	1.97
MK-1775 0.32μM R02 exp75	2.03
BI-6727 0.04μM R03 exp98	2.04
Resveratrol 16μM R03 exp147	2.18
3-Bromopyruvate 7μM R04 exp175	2.28
JQ1 0.8μM R08 exp435	2.49
BML-284 0.09μM R08 exp460	2.53
Olaparib 4μM R08 exp512	3.07
Aminopterin 0.005μM R07 exp335	4.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

production of miRNAs involved in gene silencing by miRNA
miRNA binding
production of small RNA involved in gene silencing by RNA
dsRNA processing
gene silencing by miRNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
gene silencing by RNA
gene silencing
regulation of gene expression, epigenetic
posttranscriptional regulation of gene expression
RNA processing
RNA binding
RNA metabolic process
negative regulation of gene expression
gene expression