C14orf169

Entrez Summary: N/A
UniProt Summary: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide 2000μM R01 exp50	-1.95
Beta-Estradiol 0.55μM R07 exp425	-1.71
TRAIL 5ng/ml R00 exp35	1.71
Trichostatin-A 0.06μM R07 exp415	1.81
Dimethyloxaloylglycine 100μM R05 exp229	1.83
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.83
Ethanol 0.01 R05 exp234	2.08
MS023 2μM R03 exp134	2.25
RO-3307 4.7μM R02 exp80	2.31
LY2090314 0.003μM R08 exp500 no dilution day6	2.52
LY2090314 0.003μM R08 exp499	3.02

Expression Distribution

histone demethylase activity (H3-K4 specific)
histone H3-K4 demethylation
histone demethylase activity (H3-K36 specific)
histone H3-K36 demethylation
2-oxoglutarate-dependent dioxygenase activity
histone lysine demethylation
histone demethylation
protein dealkylation
protein demethylation
negative regulation of osteoblast differentiation
demethylation
negative regulation of ossification
regulation of osteoblast differentiation
iron ion binding
regulation of ossification
histone modification
covalent chromatin modification
chromatin organization
negative regulation of cell differentiation
nucleolus
negative regulation of developmental process
oxidation-reduction process
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression
regulation of cell differentiation