CAPRIN1

Gene Information

Official Symbol: CAPRIN1
Official Name: cell cycle associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 4076
UniProt: Q14444
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.45
Golgicide-A 4μM R03 exp122	-1.85
Methotrexate 0.01μM R08 exp501	-1.83
MLN-4924 0.2μM R00 exp21	-1.78
3-Bromopyruvate 7μM R04 exp175	-1.77
Tubastatin-A 2.5μM R07 exp417	-1.76
LY2090314 0.003μM R08 exp499	-1.75
MS023 2μM R03 exp134	-1.75
AICAR 240μM R05 exp211	1.73
42°C R08 exp539	1.75
Cerivastatin 0.15μM R05 exp226	1.8
UMK57 1μM R01 exp59	1.82
Brefeldin A 0.02μM R00 exp8	1.84
NMS-873 0.07μM R07 exp380	1.91
Deferoxamine 11μM R07 exp350	1.92
Hydroxyurea 100μM R07 exp329	1.92
CR131-b 0.005μM R08 exp474	1.94
Oligomycin-A 2μM R00 exp25	1.97
Q15 2.7μM R02 exp79	2.24
RK-33 8μM R08 exp518	2.29
Dynasore 10μM R04 exp180	2.36
Phenformin 20μM R05 exp212	2.39
UM131593 0.2μM R03 exp106	3.04

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3535
Expression level (log2 read counts): 8.71

Expression Distribution

positive regulation of dendritic spine morphogenesis
positive regulation of dendrite morphogenesis
regulation of dendritic spine morphogenesis
positive regulation of dendritic spine development
cytoplasmic stress granule
regulation of dendritic spine development
positive regulation of dendrite development
P-body
regulation of dendrite morphogenesis
regulation of postsynapse organization
negative regulation of translation
negative regulation of cellular amide metabolic process
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
regulation of synapse organization
regulation of synapse structure or activity
synapse
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
regulation of translation
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of cellular amide metabolic process
dendrite
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
posttranscriptional regulation of gene expression
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
negative regulation of cellular protein metabolic process
regulation of anatomical structure morphogenesis
negative regulation of protein metabolic process