ENTPD4

Gene Information

Official Symbol: ENTPD4
Official Name: ectonucleoside triphosphate diphosphohydrolase 4
Aliases and Previous Symbols: N/A
Entrez ID: 9583
UniProt: Q9Y227
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].
UniProt Summary: Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP » GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Fluvastatin 2.2μM R06 exp282	-3.77
Bafilomycin-A1 0.009μM R08 exp454	-3.26
Cerivastatin 0.15μM R05 exp226	-2.96
CoCl2 18μM R07 exp346	-2.08
Arsenate 40μM R06 exp264	-1.83
ETC-159 50μM R08 exp480	-1.81
CFI-400945 25μM R08 exp469	-1.7
Pomalidomide 20μM R07 exp391	1.75
A-395N 10μM R05 exp219	1.89
Lead acetate 2000μM R08 exp498 no dilution day6	2.64

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16272
Expression level (log2 read counts): 6.79

Expression Distribution

Gene	Correlation
SLC35E1	0.469
SLC39A9	0.459

pyrimidine ribonucleotide catabolic process
UDP catabolic process
UDP metabolic process
pyrimidine ribonucleoside diphosphate metabolic process
pyrimidine nucleoside diphosphate catabolic process
pyrimidine ribonucleoside diphosphate catabolic process
integral component of autophagosome membrane
pyrimidine nucleoside diphosphate metabolic process
uridine-diphosphatase activity
ribonucleoside diphosphate catabolic process
nucleoside diphosphate catabolic process
pyrimidine nucleotide catabolic process
pyrimidine ribonucleotide metabolic process
ribonucleotide catabolic process
pyrimidine-containing compound catabolic process
nucleobase-containing small molecule catabolic process
pyrimidine nucleotide metabolic process
integral component of Golgi membrane
ribonucleoside diphosphate metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside diphosphate metabolic process
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
cytoplasmic vesicle
ribonucleotide metabolic process
ribose phosphate metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
Golgi membrane