FOXK1

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor cell population (By similarity). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity). Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dinaciclib 0.007μM R07 exp355	-2.11
Bisphenol S 100μM R08 exp458	-1.92
MK2206 4μM R08 exp504	-1.86
Vincristine 0.0005μM R04 exp190	-1.84
3-Bromopyruvate 7μM R04 exp175	1.72
A-395 10μM R05 exp218	1.73
Docosahexaenoic-acid 50μM R07 exp356	1.73
All-trans-Retinoic-Acid 40μM R07 exp334	1.75
Deferoxamine 11μM R07 exp350	2.13
Nocodazole 0.2μM R02 exp64	2.23
SB743921 0.001μM R05 exp244	2.28
Nocodazole 0.1μM R03 exp94	3.08
DABN racemic mixture R03 exp93	3.13
LY2090314 0.003μM R08 exp500 no dilution day6	3.7
LY2090314 0.003μM R08 exp499	4.84

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Fork head
FHA

regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
canonical glycolysis
NADH regeneration
glucose catabolic process to pyruvate
glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate
14-3-3 protein binding
glucose catabolic process
NADH metabolic process
glycolytic process
ATP generation from ADP
regulation of gluconeogenesis
NAD metabolic process
ADP metabolic process
hexose catabolic process
nucleoside diphosphate phosphorylation
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
transcription regulatory region sequence-specific DNA binding
nucleoside diphosphate metabolic process
negative regulation of autophagy
cellular glucose homeostasis
regulation of carbohydrate biosynthetic process
glucose metabolic process
regulation of glucose metabolic process
carbohydrate catabolic process
regulation of cellular carbohydrate metabolic process
hexose metabolic process
glucose homeostasis
carbohydrate homeostasis
response to starvation
monosaccharide metabolic process
regulation of carbohydrate metabolic process
ATP metabolic process
DNA-binding transcription repressor activity, RNA polymerase II-specific