GJB1
Gene Information
- Official Symbol: GJB1
- Official Name: gap junction protein beta 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2705
- UniProt: P08034
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008].
- UniProt Summary: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18539
- Expression level (log2 read counts): -5.01
GJB1 Expression in NALM6 Cells: -5.01
