KBTBD7

Entrez Summary: The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
OICR-9429 10μM R03 exp142	-2.56
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.13
Benzoate 10000μM R08 exp455	-2
Mubritinib 0.2μM R01 exp48	-1.91
IL-3 9ng/ml R08 exp493	-1.75
Taxol 0.002μM R01 exp54	1.71
Caffeine 2600μM R08 exp463	1.8
A-395N 10μM R05 exp219	1.91
Celastrol 0.12μM R05 exp225	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

post-translational protein modification
MAPK cascade
signal transduction by protein phosphorylation
cellular component
molecular function
protein phosphorylation
phosphorylation
intracellular signal transduction