KMT2E
Gene Information
- Official Symbol: KMT2E
- Official Name: lysine methyltransferase 2E
- Aliases and Previous Symbols: N/A
- Entrez ID: 55904
- UniProt: Q8IZD2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SET |
| PHD |
GO Terms
| positive regulation of histone H3-K4 trimethylation |
| regulation of histone H3-K4 trimethylation |
| positive regulation of histone H3-K4 methylation |
| histone-lysine N-methyltransferase activity |
| transcriptionally active chromatin |
| regulation of histone H3-K4 methylation |
| positive regulation of G1/S transition of mitotic cell cycle |
| positive regulation of histone methylation |
| positive regulation of cell cycle G1/S phase transition |
| DNA alkylation |
| DNA methylation |
| regulation of megakaryocyte differentiation |
| methylated histone binding |
| regulation of histone methylation |
| DNA methylation or demethylation |
| histone lysine methylation |
| positive regulation of mitotic cell cycle phase transition |
| erythrocyte differentiation |
| peptidyl-lysine methylation |
| DNA modification |
| erythrocyte homeostasis |
| positive regulation of histone modification |
| histone methylation |
| positive regulation of cell cycle phase transition |
| positive regulation of chromatin organization |
| myeloid cell homeostasis |
| chromatin |
| protein methylation |
| protein alkylation |
| regulation of histone modification |
| cell cycle arrest |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| microtubule organizing center |
| regulation of cell cycle G1/S phase transition |
| positive regulation of chromosome organization |
| regulation of chromatin organization |
| homeostasis of number of cells |
| myeloid cell differentiation |
| regulation of myeloid cell differentiation |
| macromolecule methylation |
| positive regulation of cell cycle process |
| methylation |
| peptidyl-lysine modification |
| enzyme binding |
| regulation of chromosome organization |
| histone modification |
| covalent chromatin modification |
| positive regulation of cell cycle |
| nuclear speck |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| regulation of hemopoiesis |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| myeloid leukocyte mediated immunity |
| hemopoiesis |
| negative regulation of cell cycle |
| myeloid leukocyte activation |
| protein-containing complex |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| immune system development |
| chromatin organization |
| DNA metabolic process |
| regulation of cell cycle process |
| leukocyte mediated immunity |
| peptidyl-amino acid modification |
| leukocyte activation |
| cell cycle process |
| chromosome organization |
| cell activation |
| immune effector process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of organelle organization |
| cell cycle |
| positive regulation of transcription, DNA-templated |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ANKRD11 | 0.495 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7982
- Expression level (log2 read counts): 7.51
Expression Distribution
KMT2E Expression in NALM6 Cells: 7.51
