PIP4K2A

Entrez Summary: N/A
UniProt Summary: Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000269|PubMed:18364242}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-phosphatidylinositol-5-phosphate 4-kinase activity
1-phosphatidylinositol-4-phosphate 5-kinase activity
positive regulation of autophagosome assembly
positive regulation of vacuole organization
megakaryocyte development
megakaryocyte differentiation
bone cell development
regulation of autophagosome assembly
regulation of vacuole organization
phosphatidylinositol phosphorylation
myeloid cell development
lipid phosphorylation
positive regulation of macroautophagy
autophagosome
positive regulation of organelle assembly
phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of autophagy
phosphatidylinositol metabolic process
regulation of macroautophagy
bone development
lipid modification
glycerophospholipid biosynthetic process
myeloid cell differentiation
regulation of organelle assembly
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
regulation of autophagy
positive regulation of cellular catabolic process
phospholipid metabolic process
glycerolipid metabolic process
positive regulation of catabolic process
skeletal system development
positive regulation of cellular component biogenesis
organophosphate biosynthetic process
hemopoiesis
lipid biosynthetic process
hematopoietic or lymphoid organ development
positive regulation of organelle organization