PRUNE

Entrez Summary: This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DHH
DHHA2

inorganic diphosphatase activity
exopolyphosphatase activity
polyphosphate catabolic process
polyphosphate metabolic process
phosphatase activity
regulation of microtubule polymerization
tubulin binding
regulation of microtubule polymerization or depolymerization
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
dephosphorylation
regulation of supramolecular fiber organization
focal adhesion
regulation of protein complex assembly
regulation of cytoskeleton organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
regulation of cellular component biogenesis
oxoacid metabolic process
organic acid metabolic process
regulation of organelle organization
generation of neurons
neurogenesis
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
regulation of cell differentiation