AGPAT6

Entrez Summary: N/A
UniProt Summary: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. {ECO:0000269|PubMed:18238778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R03 exp143	-2.95
CCT251545 20μM R07 exp326	-2.62
UM0011500 10μM R05 exp246	-2.28
Ibrutinib 10μM R08 exp442	-2.1
UM0125461 0.74μM R02 exp84	-1.92
Prochlorperazine 5.2μM R02 exp77	-1.86
NMS-873 0.07μM R07 exp380	-1.85
Cycloheximide 0.02μM R00 exp14	-1.84
All-trans-Retinoic-Acid 8μM R07 exp333	-1.82
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.8
UM0131023 0.05μM R05 exp248	-1.8
A-769662 20μM R07 exp331	-1.77
FK-506 5μM R07 exp358	-1.75
Chloramphenicol 2μM R00 exp12	-1.7
Lapatinib 5μM R01 exp47	-1.7
Nifuroxazide 5μM R03 exp102	-1.7
Pyronaridine 1μM R06 exp295	-1.7
Isonicotinamide 500μM R03 exp129	1.72
Q15 1 to 2μM on day4 R04 exp164	2.74
Vemurafenib 6.6μM R08 exp434	2.87
Vemurafenib 6.6μM R02 exp89	3.09
Q15 2.7μM R02 exp79	6.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glandular epithelial cell maturation
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
glycerol-3-phosphate O-acyltransferase activity
columnar/cuboidal epithelial cell maturation
CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
epithelial cell maturation
1-acylglycerol-3-phosphate O-acyltransferase activity
glandular epithelial cell development
triglyceride biosynthetic process
diacylglycerol metabolic process
neutral lipid biosynthetic process
acylglycerol biosynthetic process
phosphatidylcholine biosynthetic process
glandular epithelial cell differentiation
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
lactation
pyrimidine nucleotide biosynthetic process
columnar/cuboidal epithelial cell development
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
regulation of multicellular organism growth
body fluid secretion
triglyceride metabolic process
phosphatidylcholine metabolic process
columnar/cuboidal epithelial cell differentiation
thioester metabolic process
acyl-CoA metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
pyrimidine-containing compound metabolic process
mammary gland development
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
anatomical structure maturation
cell maturation
epithelial cell development
ammonium ion metabolic process