ALG12

Entrez Summary: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008].
UniProt Summary: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP- Man(7)GlcNAc(2)) required for protein glycosylation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.52
Bortezomib 0.005μM R00 exp6	-2.22
Bisphenol F 50μM R08 exp457	-2.2
Trametinib 10μM R02 exp83	-2.15
Bisphenol A 100μM R06 exp269	-2.03
39°C R06 exp303	-1.98
Nicotinamide 1000μM R03 exp101	-1.92
Cincreasin 100μM R08 exp473	-1.89
PFI-2 4μM R05 exp239	-1.88
Dynasore 10μM R04 exp180	-1.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.72
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.7
SB203580 25μM R03 exp149	1.76

Global Fraction of Cell Lines Where Essential: 17/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	7/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity
dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
mannosyltransferase activity
mannosylation
protein N-linked glycosylation
protein folding
macromolecule glycosylation
protein glycosylation
glycosylation
endoplasmic reticulum lumen
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane