ALG3

Entrez Summary: This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
UniProt Summary: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. {ECO:0000269|PubMed:10581255}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.58
Bisphenol S 100μM R08 exp458	-2.4
proTAME 5μM R04 exp187	-2.38
Dynasore 10μM R04 exp180	-2.15
Bafilomycin-A1 0.009μM R08 exp454	-2.1
Thapsigargin 0.005μM R07 exp407	-2.05
Cincreasin 100μM R08 exp473	-1.91
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.86
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.84
Betulinic acid 10 to 15μM on day4 R05 exp222	1.7
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.71
Mitomycin-C 0.06μM R08 exp503	1.78
Bleomycin 5μM R08 exp459	1.92
Amiloride 100μM R08 exp447	1.99
Milciclib 2μM R08 exp502	2.03
SNS-032 15μM R08 exp443	2.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
alpha-1,3-mannosyltransferase activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
mannosylation
protein N-linked glycosylation
integral component of endoplasmic reticulum membrane
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process