ATPIF1

Gene Information

Official Symbol: ATP5IF1
Official Name: ATP synthase inhibitory factor subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 93974
UniProt: Q9UII2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-1.87
RK-33 8μM R08 exp518	-1.75
CFI-400945 25μM R08 exp469	1.7
Temozolomide 200μM R04 exp189	1.72
CR131-b 0.005μM R08 exp474	1.77
Senexin-A 25μM R07 exp400	1.77
BS-181 20μM R08 exp461	1.82
Caffeine 2600μM R08 exp463	2
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	2.12
Vincristine 0.0005μM R04 exp190	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7238
Expression level (log2 read counts): 5.79

Expression Distribution

mitochondrial proton-transporting ATP synthase complex binding
mitochondrial depolarization
angiostatin binding
ATPase inhibitor activity
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of autophagy of mitochondrion in response to mitochondrial depolarization
positive regulation of autophagy of mitochondrion
response to mitochondrial depolarisation
negative regulation of ATPase activity
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
enzyme inhibitor activity
heme metabolic process
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of endothelial cell proliferation
porphyrin-containing compound metabolic process
regulation of autophagy of mitochondrion
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of protein targeting to mitochondrion
pigment biosynthetic process
membrane depolarization
tetrapyrrole metabolic process
pigment metabolic process
regulation of mitochondrial membrane potential
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
erythrocyte differentiation
ATPase binding
regulation of ATPase activity
regulation of membrane permeability
regulation of protein targeting
erythrocyte homeostasis
protein homotetramerization
myeloid cell homeostasis
reactive oxygen species metabolic process
positive regulation of mitochondrion organization
regulation of ATP metabolic process
positive regulation of autophagy
positive regulation of proteolysis involved in cellular protein catabolic process