BBS12

Entrez Summary: The protein encoded by this gene is part of a complex that is involved in membrane trafficking. The encoded protein is a molecular chaperone that aids in protein folding upon ATP hydrolysis. This protein also plays a role in adipocyte differentiation. Defects in this gene are a cause of Bardet-Biedl syndrome type 12. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. {ECO:0000269|PubMed:19190184, ECO:0000269|PubMed:20080638}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.01μM R03 exp130	-2.03
Pomalidomide 20μM R07 exp391	-1.91
CyclicAMP 200μM R08 exp475	-1.86
BI-6727 0.0125μM R03 exp97	1.71
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.81
2-Methoxyestradiol 0.2μM R01 exp40	1.95
Vemurafenib 6.6μM R02 exp89	2.04
Thimerosal 0.85μM R08 exp529	2.36

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chaperone-mediated protein complex assembly
eating behavior
photoreceptor cell maintenance
negative regulation of fat cell differentiation
intraciliary transport
protein transport along microtubule
microtubule-based protein transport
retina homeostasis
feeding behavior
regulation of fat cell differentiation
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
tissue homeostasis
cilium
protein-containing complex localization
microtubule-based movement
multicellular organismal homeostasis
anatomical structure homeostasis
cilium organization
behavior
microtubule-based process
negative regulation of cell differentiation
cellular protein-containing complex assembly
negative regulation of developmental process
intracellular protein transport
plasma membrane bounded cell projection organization
cell projection organization
ATP binding
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
homeostatic process
regulation of cell differentiation