BID
Gene Information
- Official Symbol: BID
- Official Name: BH3 interacting domain death agonist
- Aliases and Previous Symbols: N/A
- Entrez ID: 637
- UniProt: P55957
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269|PubMed:14583606}.
Pfam Domains GO Terms
Pfam Domains
| BID |
GO Terms
| positive regulation of fibroblast apoptotic process |
| integral component of mitochondrial membrane |
| positive regulation of protein homooligomerization |
| positive regulation of mitochondrial membrane potential |
| hepatocyte apoptotic process |
| mitochondrial outer membrane permeabilization |
| positive regulation of membrane potential |
| death receptor binding |
| positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| regulation of fibroblast apoptotic process |
| mitochondrial outer membrane permeabilization involved in programmed cell death |
| regulation of protein homooligomerization |
| positive regulation of mitochondrial membrane permeability |
| release of cytochrome c from mitochondria |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| positive regulation of membrane permeability |
| positive regulation of protein oligomerization |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| epithelial cell apoptotic process |
| positive regulation of release of cytochrome c from mitochondria |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| extrinsic apoptotic signaling pathway via death domain receptors |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of protein oligomerization |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| neuron apoptotic process |
| regulation of release of cytochrome c from mitochondria |
| positive regulation of extrinsic apoptotic signaling pathway |
| neuron death |
| positive regulation of establishment of protein localization to mitochondrion |
| positive regulation of intrinsic apoptotic signaling pathway |
| protein targeting to mitochondrion |
| apoptotic mitochondrial changes |
| establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane potential |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| protein localization to mitochondrion |
| negative regulation of response to DNA damage stimulus |
| regulation of membrane permeability |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial ATP synthesis coupled electron transport |
| ATP synthesis coupled electron transport |
| negative regulation of intrinsic apoptotic signaling pathway |
| extrinsic apoptotic signaling pathway |
| signal transduction in response to DNA damage |
| respiratory electron transport chain |
| positive regulation of mitochondrion organization |
| oxidative phosphorylation |
| positive regulation of protein localization to membrane |
| mitochondrial membrane organization |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of intrinsic apoptotic signaling pathway |
| mitochondrial outer membrane |
| regulation of cell cycle G1/S phase transition |
| cellular respiration |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| electron transport chain |
| regulation of protein localization to membrane |
| positive regulation of peptidase activity |
| ATP metabolic process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| energy derivation by oxidation of organic compounds |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| establishment of protein localization to membrane |
| apoptotic signaling pathway |
| ubiquitin protein ligase binding |
| positive regulation of cellular protein localization |
| protein homooligomerization |
| positive regulation of proteolysis |
| protein targeting |
| regulation of apoptotic signaling pathway |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| generation of precursor metabolites and energy |
| regulation of membrane potential |
| establishment of protein localization to organelle |
| mitochondrion organization |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| positive regulation of establishment of protein localization |
| protein localization to membrane |
| protein heterodimerization activity |
| negative regulation of intracellular signal transduction |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of cellular protein localization |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cellular response to stress |
| protein localization to organelle |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| membrane organization |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| apoptotic process |
| regulation of cellular component biogenesis |
| oxidation-reduction process |
| positive regulation of transport |
| intracellular protein transport |
| negative regulation of cell death |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| programmed cell death |
| cell death |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LLY-284 2.6μM R06 exp291 | 1.71 |
| Latrunculin-B 10μM R07 exp374 | 1.79 |
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3239
- Expression level (log2 read counts): 5.46
Expression Distribution
BID Expression in NALM6 Cells: 5.46
