BMPER

Entrez Summary: This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011].
UniProt Summary: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. {ECO:0000269|PubMed:14766204}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

blood vessel endothelial cell proliferation involved in sprouting angiogenesis
endothelial cell activation
endothelial cell proliferation
positive regulation of sprouting angiogenesis
negative regulation of BMP signaling pathway
sprouting angiogenesis
regulation of pathway-restricted SMAD protein phosphorylation
regulation of sprouting angiogenesis
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
epithelial cell proliferation
regulation of BMP signaling pathway
mesonephros development
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
kidney epithelium development
negative regulation of cellular response to growth factor stimulus
regulation of endothelial cell migration
positive regulation of angiogenesis
positive regulation of vasculature development
inner ear development
positive regulation of ERK1 and ERK2 cascade
regulation of epithelial cell migration
ear development
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
kidney development
regulation of cellular response to growth factor stimulus
renal system development
regulation of angiogenesis
regulation of ERK1 and ERK2 cascade
angiogenesis
urogenital system development
regulation of vasculature development
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
positive regulation of MAPK cascade
sensory organ development
cell population proliferation