BRCC3

Entrez Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.23
LY2090314 0.003μM R08 exp500 no dilution day6	-2.15
TRAIL 5ng/ml R00 exp35	-1.92
Etoposide 0.1μM R05 exp198	-1.89
THZ531 0.225μM R08 exp444	-1.83
42°C R08 exp539	1.7
GSK2606414 1μM R05 exp236	1.71
GSK626616 14μM R08 exp485	1.73
Cyclosporin-A 3μM R07 exp348	1.76
VE-822 0.04μM R06 exp300	1.76
Etoposide 1μM R00 exp19	1.77
MS023 2μM R03 exp134	1.83
MS023 7μM R03 exp135	1.89
Pimelic-diphenylamide-106 5μM R00 exp28	1.91
Calcium Ionophore 0.4μM R07 exp342	1.93
BAY-598 4μM R05 exp220	1.94
Demecolcine 0.03μM R05 exp228	1.95
QNZ 0.01μM R05 exp241	1.98
I-BRD9 4μM R07 exp365	2.25
BVD-523 15μM R02 exp67	2.28

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

nuclear ubiquitin ligase complex
histone H2A K63-linked deubiquitination
BRISC complex
BRCA1-A complex
Lys63-specific deubiquitinase activity
signal transduction involved in G2 DNA damage checkpoint
enzyme regulator activity
histone deubiquitination
G2 DNA damage checkpoint
response to X-ray
polyubiquitin modification-dependent protein binding
protein K63-linked deubiquitination
thiol-dependent ubiquitinyl hydrolase activity
double-strand break repair via nonhomologous end joining
metallopeptidase activity
non-recombinational repair
positive regulation of DNA repair
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
positive regulation of response to DNA damage stimulus
negative regulation of cell cycle G2/M phase transition
signal transduction in response to DNA damage
ubiquitin ligase complex
thiol-dependent ubiquitin-specific protease activity
spindle pole
regulation of DNA repair
DNA damage checkpoint
DNA integrity checkpoint
response to ionizing radiation
double-strand break repair
positive regulation of DNA metabolic process
cell cycle checkpoint
regulation of cell cycle G2/M phase transition
regulation of response to DNA damage stimulus
negative regulation of cell cycle phase transition
protein deubiquitination
protein modification by small protein removal
negative regulation of cell cycle process
regulation of DNA metabolic process