C11orf30

Entrez Summary: N/A
UniProt Summary: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pifithrin-alpha 20μM R07 exp390	-2.16
Radicicol 0.16μM R05 exp242	-2.16
BI-2536 0.0042μM R03 exp95	-2.14
Citral 75μM R06 exp275	-2.06
Pimelic-diphenylamide-106 5μM R00 exp28	-1.97
Actinomycin-D 0.001μM R00 exp3	-1.91
A-769662 20μM R07 exp331	-1.89
2-Methoxyestradiol 0.55μM R07 exp310	-1.87
PT-1 25μM R07 exp392	-1.82
Chloramphenicol 2μM R00 exp12	-1.78
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.77
BI-6727 0.001μM R01 exp42	-1.74
Atovaquone 15μM R08 exp451	1.83
ONC212 0.15μM R08 exp513	1.84
Genistein 15μM R07 exp360	1.87
Doxorubicin 0.02μM R08 exp478	1.95
GSK-J4 1.5μM R08 exp441	1.99

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA repair
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
protein homodimerization activity
chromosome organization
cellular response to stress