C21orf59
Gene Information
- Official Symbol: CFAP298
- Official Name: cilia and flagella associated protein 298
- Aliases and Previous Symbols: N/A
- Entrez ID: 56683
- UniProt: P57076
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017].
- UniProt Summary: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 375
- Expression level (log2 read counts): 5.29
C21ORF59 Expression in NALM6 Cells: 5.29
