CASP10

Gene Information

Official Symbol: CASP10
Official Name: caspase 10
Aliases and Previous Symbols: N/A
Entrez ID: 843
UniProt: Q92851
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pomalidomide 20μM R07 exp391	-2.09
VE-822 0.04μM R06 exp300	-2.05
BI-2536 0.02μM R03 exp96	-1.92
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.8
Bisphenol S 100μM R08 exp458	-1.77
Vemurafenib 6.6μM R02 exp89	-1.73
PFI-2 4μM R05 exp239	1.97
Hippuristanol 0.12μM R08 exp488	2.35
TRAIL 50ng/ml R00 exp36	3.57
TRAIL 5ng/ml R00 exp35	3.65

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12327
Expression level (log2 read counts): 3.92

Expression Distribution

DED
Peptidase C14

death effector domain binding
CD95 death-inducing signaling complex
ripoptosome
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
cysteine-type endopeptidase activity involved in apoptotic process
execution phase of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
ubiquitin protein ligase binding
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
apoptotic process
positive regulation of intracellular signal transduction
programmed cell death
cell death
proteolysis
regulation of hydrolase activity
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
regulation of cell death
positive regulation of protein metabolic process
positive regulation of molecular function