CFLAR
Gene Information
- Official Symbol: CFLAR
- Official Name: CASP8 and FADD like apoptosis regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 8837
- UniProt: O15519
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DED |
| Peptidase C14 |
GO Terms
| negative regulation of hepatocyte apoptotic process |
| regulation of hepatocyte apoptotic process |
| negative regulation of myoblast fusion |
| negative regulation of syncytium formation by plasma membrane fusion |
| positive regulation of glomerular mesangial cell proliferation |
| ripoptosome |
| CD95 death-inducing signaling complex |
| death-inducing signaling complex |
| skeletal muscle atrophy |
| positive regulation of cell proliferation involved in kidney development |
| striated muscle atrophy |
| positive regulation of hepatocyte proliferation |
| muscle atrophy |
| regulation of glomerular mesangial cell proliferation |
| peptidase activator activity |
| positive regulation of glomerulus development |
| skeletal muscle adaptation |
| negative regulation of necroptotic process |
| negative regulation of programmed necrotic cell death |
| regulation of skeletal muscle satellite cell proliferation |
| regulation of skeletal muscle cell proliferation |
| regulation of hepatocyte proliferation |
| regulation of cell proliferation involved in kidney development |
| death receptor binding |
| regulation of glomerulus development |
| cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of necrotic cell death |
| cellular response to nitric oxide |
| skeletal myofibril assembly |
| regulation of necroptotic process |
| cellular response to reactive nitrogen species |
| response to nitric oxide |
| negative regulation of myotube differentiation |
| regulation of programmed necrotic cell death |
| positive regulation of extracellular matrix organization |
| regulation of myoblast fusion |
| negative regulation of cardiac muscle cell apoptotic process |
| negative regulation of striated muscle cell apoptotic process |
| negative regulation of reactive oxygen species biosynthetic process |
| striated muscle adaptation |
| regulation of necrotic cell death |
| regulation of syncytium formation by plasma membrane fusion |
| cellular response to dexamethasone stimulus |
| muscle adaptation |
| skeletal muscle tissue regeneration |
| cellular response to estradiol stimulus |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| negative regulation of muscle cell apoptotic process |
| regulation of cardiac muscle cell apoptotic process |
| regulation of extracellular matrix organization |
| negative regulation of striated muscle cell differentiation |
| response to testosterone |
| regulation of striated muscle cell apoptotic process |
| response to dexamethasone |
| positive regulation of kidney development |
| negative regulation of epithelial cell apoptotic process |
| cellular response to epidermal growth factor stimulus |
| enzyme activator activity |
| response to epidermal growth factor |
| response to bronchodilator |
| negative regulation of reactive oxygen species metabolic process |
| negative regulation of muscle cell differentiation |
| regulation of kidney development |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| cellular response to glucocorticoid stimulus |
| regulation of myotube differentiation |
| cellular response to corticosteroid stimulus |
| tissue regeneration |
| myofibril assembly |
| regulation of muscle cell apoptotic process |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| regulation of epithelial cell apoptotic process |
| positive regulation of animal organ morphogenesis |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of reactive oxygen species biosynthetic process |
| negative regulation of cysteine-type endopeptidase activity |
| cellular response to ketone |
| response to antineoplastic agent |
| regulation of striated muscle cell differentiation |
| negative regulation of extrinsic apoptotic signaling pathway |
| protease binding |
| cellular component assembly involved in morphogenesis |
| actomyosin structure organization |
| regulation of cellular response to transforming growth factor beta stimulus |
| skeletal muscle tissue development |
| cellular response to reactive oxygen species |
| skeletal muscle organ development |
| striated muscle cell development |
| response to estradiol |
| response to glucocorticoid |
| negative regulation of cellular response to growth factor stimulus |
| muscle cell development |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of muscle cell differentiation |
| regulation of extrinsic apoptotic signaling pathway |
| regeneration |
| response to corticosteroid |
| cellular response to insulin stimulus |
| regulation of reactive oxygen species metabolic process |
| positive regulation of vasculature development |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| cellular response to hypoxia |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidase activity |
| response to ketone |
| response to reactive oxygen species |
| cellular response to decreased oxygen levels |
| striated muscle cell differentiation |
| positive regulation of ERK1 and ERK2 cascade |
| cellular response to oxygen levels |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to inorganic substance |
| negative regulation of apoptotic signaling pathway |
| membrane raft |
| response to insulin |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| muscle cell differentiation |
| negative regulation of peptidase activity |
| regulation of animal organ morphogenesis |
| positive regulation of DNA-binding transcription factor activity |
| protein-containing complex binding |
| cellular response to peptide hormone stimulus |
| regulation of cellular response to growth factor stimulus |
| positive regulation of neuron projection development |
| striated muscle tissue development |
| regulation of ERK1 and ERK2 cascade |
| muscle organ development |
| muscle tissue development |
| muscle system process |
| response to xenobiotic stimulus |
| regulation of vasculature development |
| cellular response to peptide |
| response to steroid hormone |
| regulation of epithelial cell proliferation |
| response to hypoxia |
| negative regulation of proteolysis |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| positive regulation of neuron differentiation |
| response to oxygen levels |
| positive regulation of cell projection organization |
| response to oxidative stress |
| developmental growth |
| response to peptide hormone |
| growth |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| regulation of endopeptidase activity |
| regulation of DNA-binding transcription factor activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| response to peptide |
| muscle structure development |
| wound healing |
| protein heterodimerization activity |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| cellular response to lipid |
| response to growth factor |
| response to inorganic substance |
| positive regulation of nervous system development |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| actin filament-based process |
| response to wounding |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| viral process |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| regulation of MAPK cascade |
| organelle assembly |
| positive regulation of hydrolase activity |
| symbiotic process |
| negative regulation of catalytic activity |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| response to lipid |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| cell death |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxyurea 100μM R07 exp329 | -3.66 |
| TNF-alpha 44ng/ml R08 exp533 | -2.94 |
| TRAIL 5ng/ml R00 exp35 | -2.49 |
| PU-H71 1μM R08 exp515 | -2.44 |
| TRAIL 50ng/ml R00 exp36 | -2.21 |
| THZ1 0.06μM R08 exp531 | -2.2 |
| GSK-J4 1.5μM R08 exp441 | -2.1 |
| Citral 75μM R06 exp275 | -2.03 |
| Aminopterin 0.005μM R07 exp335 | -1.95 |
| Citral 50μM R06 exp274 | -1.77 |
| Etoposide 0.3μM R05 exp199 | -1.76 |
| CB-5083 0.4μM R08 exp468 | -1.75 |
| Aphidicolin 0.4μM R08 exp440 | -1.73 |
| BH1 1μM R04 exp169 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 204/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 16/28 |
| blood | 6/28 |
| bone | 0/26 |
| breast | 9/33 |
| central nervous system | 6/56 |
| cervix | 0/4 |
| colorectal | 5/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 14/21 |
| liver | 6/20 |
| lung | 30/75 |
| lymphocyte | 7/16 |
| ovary | 12/26 |
| pancreas | 12/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 11/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 11/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 10914
- Expression level (log2 read counts): 6.7
Expression Distribution
CFLAR Expression in NALM6 Cells: 6.7
