CHAC1

Entrez Summary: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016].
UniProt Summary: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:27913623}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutathione specific gamma-glutamylcyclotransferase activity
gamma-glutamylcyclotransferase activity
glutathione catabolic process
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
Notch binding
peptide catabolic process
cellular modified amino acid catabolic process
negative regulation of protein processing
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of protein maturation
negative regulation of Notch signaling pathway
cellular modified amino acid biosynthetic process
sulfur compound catabolic process
glutathione metabolic process
cofactor catabolic process
regulation of protein processing
regulation of protein maturation
regulation of Notch signaling pathway
Notch signaling pathway
intrinsic apoptotic signaling pathway
response to unfolded protein
trans-Golgi network
sulfur compound biosynthetic process
response to topologically incorrect protein
cellular modified amino acid metabolic process
cofactor biosynthetic process
response to endoplasmic reticulum stress
apoptotic signaling pathway
negative regulation of proteolysis
sulfur compound metabolic process
peptide biosynthetic process
cofactor metabolic process
amide biosynthetic process
peptide metabolic process
regulation of proteolysis
cellular amide metabolic process
apoptotic process
negative regulation of cellular protein metabolic process
programmed cell death