CHPF2

Entrez Summary: N/A
UniProt Summary: Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N- acetylgalactosaminyltransferase activity. {ECO:0000269|PubMed:12145278, ECO:0000269|PubMed:18316376}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyl-Sulfoxide 1pc R03 exp120	-2.71
Docosahexaenoic-acid 50μM R07 exp356	-2.32
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.14
Erlotinib 10μM R05 exp216	-1.83
Ethanol 0.01 R05 exp234	-1.78
A-395 10μM R05 exp218	-1.74
2-Deoxy-D-glucose 800μM R05 exp214	-1.71
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.94
Brefeldin A 0.02μM R00 exp8	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CHGN
Fringe

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
acetylgalactosaminyltransferase activity
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
Golgi cisterna membrane
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
membrane