CUL5

Entrez Summary: N/A
UniProt Summary: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcium Ionophore 0.4μM R07 exp342	-2.12
Nicotinamide 2000μM R01 exp50	-1.99
KU-0063794 3.8μM R02 exp71	-1.85
Dimethyloxaloylglycine 100μM R05 exp229	-1.72
TIC10 10μM R08 exp532	1.71
Nifurtimox 1μM R03 exp141	1.74
VER-155008 3.9μM R06 exp301	1.77
Chlorpromazine 10μM R07 exp344	1.83
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.91
Oligomycin-A 2μM R00 exp25	2.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cullin
Cullin Nedd8

Cul5-RING ubiquitin ligase complex
cullin-RING ubiquitin ligase complex
ERBB2 signaling pathway
calcium channel activity
SCF ubiquitin ligase complex
ERBB signaling pathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
intrinsic apoptotic signaling pathway
calcium ion transmembrane transport
signaling receptor activity
ubiquitin-protein transferase activity
calcium ion transport
mitotic cell cycle phase transition
cell cycle phase transition
apoptotic signaling pathway
ubiquitin protein ligase binding
divalent metal ion transport
divalent inorganic cation transport
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
post-translational protein modification
transmembrane receptor protein tyrosine kinase signaling pathway
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
inorganic cation transmembrane transport
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cation transmembrane transport
cellular protein catabolic process
metal ion transport
inorganic ion transmembrane transport
protein catabolic process
mitotic cell cycle
protein ubiquitination
viral process
enzyme linked receptor protein signaling pathway
protein modification by small protein conjugation