CYB5R4

Entrez Summary: N/A
UniProt Summary: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	4/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	0/5

Expression Distribution

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
detection of oxygen
cytochrome-b5 reductase activity, acting on NAD(P)H
NAD(P)H oxidase activity
insulin secretion
superoxide metabolic process
bicarbonate transport
peptide hormone secretion
hormone secretion
hormone transport
reactive oxygen species metabolic process
heme binding
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
peptide secretion
glucose homeostasis
carbohydrate homeostasis
response to antibiotic
response to oxygen levels
generation of precursor metabolites and energy
organic anion transport
detection of chemical stimulus
regulation of hormone levels
anion transport
detection of stimulus
perinuclear region of cytoplasm
endoplasmic reticulum membrane
oxidation-reduction process
secretion by cell
endoplasmic reticulum
export from cell
chemical homeostasis
cell-cell signaling
secretion
response to abiotic stimulus
ion transport
protein transport
peptide transport